The oxycodone in PERCOCET may cause spasm of the sphincter of Oddi. Along with its needed effects, oxycodone may cause some unwanted effects. If oxycodone hydrochloride must be used during pregnancy, advise the patient of the risk and ensure that treatment will be available to the infant.
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Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Oxycodone/aspirin is a controlled substance because it can be misused or lead to dependence. Oxycodone/aspirin works to change how your body feels and responds to pain. It works by binding to and activating specific receptors in your body, which causes pain relief.
Medication Guide
Respiratory depression, if not immediately recognized and treated, may lead to respiratory arrest and death. Management of respiratory depression may include close observation, supportive measures, and use of opioid antagonists, depending on the patient’s clinical status see OVERDOSAGE. Carbon dioxide (CO2) retention from opioid-induced respiratory depression can exacerbate the sedating effects of opioids.
Medical Uses
If a patient is suspected to be experiencing OIH, carefully consider appropriately decreasing the dose of the current opioid analgesic or opioid rotation (safely switching the patient to a different opioid moiety) see DOSAGE AND ADMINISTRATION, WARNINGS. To reduce the risk of respiratory depression, proper dosing and titration of PERCOCET are essential see DOSAGE AND ADMINISTRATION. Overestimating the PERCOCET dosage when converting patients from another opioid product can result in a fatal overdose with the first dose. Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed PERCOCET. Healthcare providers are strongly encouraged to complete a REMS-compliant education program and to counsel patients and caregivers on serious risks, safe use, and the importance of reading the Medication Guide with each prescription see WARNINGS.
- There are no known interactions between oxycodone/aspirin and foods or drinks.
- If after increasing the dosage, unacceptable opioid-related adverse reactions are observed (including an increase in pain after dosage increase), consider reducing the dosage see WARNINGS.
- Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression.
Precautions
Becoming physically dependent on a drug is not the same as having an addiction, but physical dependence often accompanies addiction. Both of these medications have been shown to be effective in providing pain relief. There is some evidence that oxycodone in combination with other analgesics, including acetaminophen, may provide more pain relief and fewer side effects.
- Opioid analgesics, including PERCOCET, can prolong labor through actions which temporarily reduce the strength, duration, and frequency of uterine contractions.
- Roxicodone (oxycodone) is an opioid analgesic prescribed to treat moderate to severe pain.
- Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.
- Increase in glucuronidation resulting in increased plasma clearance and a decreased half-life of acetaminophen.
- Oxycodone can cause serious unwanted effects if taken by adults who are not used to strong opioid pain medicines, children, or pets.
This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence). Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below.
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Warn patients not to drive or operate dangerous machinery unless they are tolerant to the effects of ROXICODONE and know how they will react to the medication see Patient Counseling Information. Table 1 includes clinically significant drug interactions with ROXICODONE. This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine. This is not a complete list of side effects and other serious side effects may occur.
Elderly patients (aged 65 years or older) may have increased sensitivity PERCOCET. Evaluate patients for signs of urinary retention or reduced gastric motility when PERCOCET is used concomitantly with anticholinergic drugs. If concomitant use is warranted, frequently evaluate the patient, particularly during treatment initiation and dose adjustment. Although oxycodone may cross-react with some drug urine tests, no available studies were found which determined the duration of detectability of oxycodone in urine drug screens. However, based on pharmacokinetic data, the approximate duration of detectability for a single dose of oxycodone is roughly estimated to be one to two days following drug exposure.
Monitor for respiratory depression, especially when beginning treatment or increasing dose. Before prescribing, assess the patient’s risk and watch for signs of the development of these behaviors. Below is a table that compares the use of this medicine for pain relief to non-opioid alternatives. The higher the dosage, the more likely you are to get complications.
“Drug-seeking” behavior is very common in persons with substance use disorders. “Doctor shopping” (visiting multiple prescribers to obtain additional prescriptions) is common among people who abuse drugs and people with substance use disorder. Preoccupation with achieving adequate pain relief can be percocet: uses, dosage, side effects warnings appropriate behavior in a patient with inadequate pain control. Inform patients and caregivers not to increase opioid dosage without first consulting a clinician.
There are no data on the effects of the oxycodone on milk production. In studies conducted by the National Toxicology Program, fertility assessments with acetaminophen have been completed in Swiss CD-1 mice via a continuous breeding study. There were no effects on fertility parameters in mice consuming up to 1.7 times the MHDD of acetaminophen, based on a body surface area comparison.